Gold(I)-catalyzed intra- and intermolecular hydroamination of unactivated olefins.
نویسندگان
چکیده
Ph3PAuOTf catalyzes efficient intra- and intermolecular hydroamination of unactivated olefins with sulfonamides.
منابع مشابه
Iridium-catalyzed intermolecular hydroamination of unactivated aliphatic alkenes with amides and sulfonamides.
The intermolecular addition of N-H bonds to unactivated alkenes remains a challenging, but desirable, strategy for the synthesis of N-alkylamines. We report the intermolecular amination of unactivated α-olefins and bicycloalkenes with arylamides and sulfonamides to generate synthetically useful protected amine products in high yield. Mechanistic studies on this rare catalytic reaction revealed ...
متن کاملGold(I)-catalyzed intramolecular hydroamination of unactivated alkenes with carboxamides.
N-Alkenyl carboxamides undergo gold-catalyzed intramolecular exo-hydroamination to form nitrogen heterocycles in excellent yield.
متن کاملGold(I)-catalyzed intramolecular hydroamination of unactivated C==C bonds with alkyl ammonium salts.
A mixture of (5)AuCl [ = PCy2[2-(2,6-C6H3(OMe)2)C6H4]] and AgOTf catalyzes the intramolecular hydroamination of unactivated C==C bonds with primary and secondary ammonium salts.
متن کاملORGANIC CHEMISTRY. Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines.
Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Here, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins—an important yet unexploited class of abundant feedstock chemicals—into highly enantioenriched α-bran...
متن کاملPlatinum(II)-catalyzed intermolecular hydroarylation of unactivated alkenes with indoles.
Ethylene, alpha-olefins, and vinyl arenes undergo platinum-catalyzed hydroarylation with substituted indoles in moderate to good yield.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 128 6 شماره
صفحات -
تاریخ انتشار 2006